LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice
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چکیده
منابع مشابه
LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.
Although widely prescribed for their potent antiinflammatory actions, glucocorticoid drugs (e.g., dexamethasone) cause undesirable side effects that are features of the metabolic syndrome, including hyperglycemia, fatty liver, insulin resistance, and type II diabetes. Liver x receptors (LXRs) are nuclear receptors that respond to cholesterol metabolites and regulate the expression of a subset o...
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Corticosteroid-induced hyperglycemia is a common medical problem that can lead to frequent emergency room visits, hospital admissions and prolonged hospital stay, in addition to the well known morbidity associated with hyperglycemia. However, the diagnosis and treatment of corticosteroid-induced hyperglycemia is surprisingly undervalued by most professionals, probably because of the lack of qua...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2011
ISSN: 0021-9738
DOI: 10.1172/jci41681